Nolvadex is the trade name possessed by a chemical Tamoxifen Citrate that was 1st innovated in 1961 by ICI that is now Astra Zeneca.
It is the selective estrogenic receptor modulator that has the ability to modulate the estrogenic receptor according to the need of the person, it perform dual function of agonism and antagonism of estrogen hormone.
Due to its anti-estrogenic property it is selected by steroids user as a post cycle therapy to counter the adverse effect of anabolic steroids.
In actual it was 1st designed for the treatment of breast cancer corresponding with the hormonal misbalance and could also be useful for the prevention of the breast cancer.
IS NOLVADEX LEGAL?
A General Law to be enforced by ministry of health of the different states that:
Prescription drugs that are recommended by physicians are to be purchase only by showing the official written prescription of registered medical practitioner.
Pharmacy medicines can be sold without prescription but under the supervision of licensed pharmacist.
General sales list medicine can be sold on any shop.
Nolvedex comes under the 1stcategory. It is legal to purchase it but after showing the prescription. Online black marketers are flowing all over the internet but they are totally illegal and Un lawful.
MECHANISM OF ACTION:
Nolvadex belongs to the class selective estrogen receptor modulator, it is actually a prodrug binds to the estrogen receptor and induce the conformational change in the estrogen dependent genes that cause the process of activation and inhibition of estrogen hormone. Activation occurs by change in the gene expression and inhibition by the blockage of binding of estrogen hormone to its receptors.
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Due to which decrease in estradiol uptake and result in inhibition of estrogenic responses.
In the same way nolvadex also binds to other coactivators and compressors in the tissue and binds to other estrogenic receptors producing both agonism (activation of estrogenic activities) and antagonism (inhibition of estrogenic activities).
CYCLE OF NOLVADEX:
The nolvadex cycle for post cycle therapy of anabolic steroids is of 1-4 weeks usually but can extended to 1 to 6 weeks if anabolic steroids cycle was too strong.
The dose of nolvadex started from 40mg in the 1st and 2nd week that gradually decline to 20mg in the 3rd and 4th week.
If the cycle is extended to 5th and 6th week it remained continued with the dose of 20mg in the 5th and again 20mg per day in the 6th week.
While the on cycle therapy of gynecomastia ranges from 10mg to 20mg per day.
The discussed cycle patterns are not to be taken by person themselves a doctor should be consult before starting with such supplements and cycles are discussed as well.
The dosage pattern of nolvadex dependent upon the condition for which it is using .it is used by the women for boosting testosterone concentration in few conditions, also can be used for on cycle therapy of steroids, post cycle therapy of anabolic steroids and dose may vary in all these conditions but ranging between 10mg to 40 mg.
In case of female athletes for enhancing the testosterone level and to bind estrogen its dose would be set at 10mg per day and rarely could be exceed to 20mg per day but that is uncommon.
On cycle therapy:
In the prevention of gynecomastia that is caused by the aromatization of testosterone and increase in the estrogen concentration that develop feminine characters, in order to counter the binding of estrogen to its receptor nolvadex 10mg intake per day is necessary that could need to elevate till 20mg.
In few cases of aromatization the un limited amount of nolvadex is not remained enough to counter the gynecomastia.
Post cycle therapy:
The post cycle therapy is carried on for the purpose of re-balancing the natural testosterone release that is suppressed due to the anabolic steroids use.
The dose started in most men from the 40mg per day then it gradually decline to 20mg at the end of the therapy till 4 weeks or in few cases needed till 6 weeks.
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ADVERSE EFFECTS OF NOLVADEX:
Nolvadex does not produce much severe side effects as other hormonal drugs. Common effects produce in women using nolvedex are:
Vaginal itching, discomfort, vaginal discharge and bleeding, headache, nausea, vomiting, stomach upset.
Few rare effects produced by the nolvadex are:
- Leucopenia (decreased white blood cells count)
- Endometrial and myometrial changes.
- Pulmonary embolism.
- Increased fatty acid and triglycerides level.
In few patients it could cause reduce cognitive abilities and gradually lead towards state of dementia (loss of partial memory).
Some other side effects which hurdles with daily routine of individuals are commonly reported are:
- Loss of sexual ability.
- Hair thinning.
- Muscles weakness.
- Swelling of joints.
These all are there to reduce the body stamina after the bouts of nolvadex.
Some unlikely and rare effects are eyes bruising, moodchanges, eyesswelling, unusualtiredness and weakness.
THERAPEUTIC EFFECTS OF NOLVADEX:
The primary effect of nolvadex is its use for the treatment and prevention of breast cancer. It is use for this purpose because of its anti-estrogenic property because estrogen tends to cause the exaggeration of breast cancer because of increase metastasis of the cancerous cells.
It is also recommended for those who have tendency to develop breast cancer by their family history.
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Nolvadex inhibit the mechanism of metastasis of cancerous cells so use along with the chemotherapy and radio therapy regimens of the cancer patient.\
In anabolic steroid user it produce best effect to reduce the estrogenic side effects produced by the steroids that tends to develop the gynecomastia and feminine characteristics.Also impact a positive results for the steroids user to counter the effect of natural testosterone suppression.
In post cycle therapy it trigger and restore the normal production of testosterone that was suppress by the anabolic steroid use so in turn causes the prevention of sexual infertility cases in man.
ONLINE BUYING OF PRODUCT:
The online buying of nolvadex is easy, quite simple and affordable, but in case of any black marketer it becomes so tough and illegal to commit the buying process.
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There is a detail interpretation of legal online buying of nolvadex and others anabolic steroids by sponsors on steroids.com. Rcl purchase is somewhat difficult comparatively but consider legal and lawful under the strict rules given by ministry of health of any state.